An Integrated Ligand- and Structure-Based Virtual Screening and Experimental Strategy for the Prediction of Chemically D

Journal of Chemical Information and Modeling · 2026-11-02 · 期刊论文

Abstract The glucagon-like peptide-1 receptor (GLP-1R) plays a central role in metabolic regulation and is a major therapeutic target for obesity and diabetes. Peptide agonists, like semaglutide, targeting GLP-1R, remain among the most effective regulators of glucose metabolism and appetite. Nonetheless, recent reports of weight regain after treatment discontinuation sustain the interest in expanding the chemical div…

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Elena Murcia García, Ning Tian, Jorge-Ricardo Alonso-Fernández 等

本文摘自《每日前沿研究简报 · 2026-11-04》「化学信息 / 药物发现」。本内容仅用于研究信息整理与科普交流，不构成医疗建议。