Nano differential scanning fluorimetry in drug discovery: advances, applications, and limitations.

Expert opinion on drug discovery · 2026-11-02 · 综述

Nano differential scanning fluorimetry monitors changes in the intrinsic tryptophan and tyrosine fluorescence of a target protein during thermal unfolding, providing a label-free approach to assessing protein stability and ligand engagement in early-stage drug discovery. The authors examine the technical differences between nano differential scanning fluorimetry and dye-based differential scanning fluorimetry, includ…

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Reyes Romero A, Dömling ASS, Groves MR.

本文摘自《每日前沿研究简报 · 2026-11-04》「化学信息 / 药物发现」。本内容仅用于研究信息整理与科普交流，不构成医疗建议。