Investigating the Toxicological Effects of 3-Phenoxybenzoic Acid Exposure on Sarcopenia via Integrated Network Toxicolog

Chemico-biological interactions · 2026-11-02 · 期刊论文

3-Phenoxybenzoic acid (3-PBA), a widespread degradation product of pyrethroid insecticides, poses potential health risks, but its mechanistic role in sarcopenia remains unclear. We integrated network toxicology, machine learning using LASSO, Elastic Net, random forest, and SVM-RFE, SHAP analysis, molecular docking, molecular dynamics simulation, and in vitro validation to investigate its underlying effects. A total o…

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Zhao P, Lu Y, Ma Z 等

本文摘自《每日前沿研究简报 · 2026-11-04》「化学信息 / 药物发现」。本内容仅用于研究信息整理与科普交流，不构成医疗建议。