From structure prediction to ligand–target recognition: expanding the reach of AlphaFold in natural product research

Natural Products and Bioprospecting · 2026-11-03 · 综述

Natural products constitute a structurally diverse reservoir of bioactive molecules and remain an important source of lead compounds for drug discovery. However, the limited availability of structural information on pharmacological targets and biomolecular interactions continues to hinder mechanism elucidation and structure-guided optimization, particularly for complex natural products such as bioactive peptides, pro…

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Guangrui Xu, Haifeng Hu, Weihui Zhao 等

本文摘自《每日前沿研究简报 · 2026-11-05》「化学信息 / 药物发现」。本内容仅用于研究信息整理与科普交流，不构成医疗建议。