Implicit Hierarchical Tensor Decomposition of Single-Cell Four-Omics Data Reveals Cell-Type-Linked Candidate Enhancer--P

bioRxiv 预印本 · 2026-11-10 · 预印本

Single-cell multi-omics provides complementary views of gene regulation, but integrating modalities with natural features comprising enhancers, genes, and three-dimensional (3D) genomic loci remains challenging. This study developed an implicit hierarchical tensor decomposition framework and applied it to the CHARM single-cell four-omics mouse brain data (GSE303006) by jointly analyzing ATAC, H3K27ac, RNA, and recons…

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Taguchi, Y.-h., Turki, T.

本文摘自《每日前沿研究简报 · 2026-11-12》「生物信息 / 组学（单细胞·差异表达）」。本内容仅用于研究信息整理与科普交流，不构成医疗建议。